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Structure-Activity Relationships of a Novel Group of Large-Conductance Ca(2+) -Activated K(+) (BK) Channel Modulators: The GoSlo-SR Family.

Roy, Subhrangsu and Morayo Akande, Adebola and Large, Roddy J. and Webb, Tim I. and Camarasu, Costin and Sergeant, Gerard P. and McHale, Noel G. and Thornbury, Keith D. and Hollywood, Mark A. (2012) Structure-Activity Relationships of a Novel Group of Large-Conductance Ca(2+) -Activated K(+) (BK) Channel Modulators: The GoSlo-SR Family. ChemMedChem. ISSN 1860-7187 (In Press)

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Abstract

Opening up ion channels: We synthesised a series of anthraquinone analogues, called the GoSlo-SR family. Their effects on bladder smooth muscle BK channels were examined and, as shown, shifted voltage dependent activation >-100 mV (at 10 μM). They were more efficacious than NS11021 and could provide a new scaffold for the design of efficacious BK openers.

Item Type: Article
Uncontrolled Keywords: Smooth muscle; Bladder; GoSlo-SR
Subjects: Science > Biology
Research Centres: Smooth Muscle Research Centre
Depositing User: Mark Hollywood
Date Deposited: 31 Aug 2012 10:51
Last Modified: 11 Nov 2014 16:10
URI: http://eprints.dkit.ie/id/eprint/242

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