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The PI-PLC inhibitor U-73122 is a potent inhibitor of the SERCA pump in smooth muscle

Hollywood, Mark A. and Sergeant, Gerard P. and Thornbury, Keith D. and McHale, Noel G. (2010) The PI-PLC inhibitor U-73122 is a potent inhibitor of the SERCA pump in smooth muscle. Br J Pharmacol., 160 (6). pp. 1293-1294.

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Abstract

In this issue MacMillan & McCarron (2010) demonstrate that the PLC inhibitor U-73122 can potently inhibit Ca2+ release from isolated smooth muscle cells independent of its effect on PLC. Their data suggest that the PLC inhibitor can block the SERCA pump in smooth muscle and cast doubt on the reliability of U-73122 as the main pharmacological tool to assess the role of the PI-PLC pathway in cellular signalling.

Item Type: Article
Uncontrolled Keywords: U-73122; PLC Inhibition; SERCA pump inhibition; Muscle, smooth; Ca2+; Cellular signalling
Subjects: Science
Research Centres: Smooth Muscle Research Centre
Depositing User: Concepta Woods
Date Deposited: 16 Nov 2011 15:18
Last Modified: 11 Nov 2014 16:10
URI: http://eprints.dkit.ie/id/eprint/61

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