Ca 2+ signalling in urethral interstitial cells of Cajal

Sergeant, Gerard P. and Hollywood, Mark A. and McHale, Noel G. (2006) Ca 2+ signalling in urethral interstitial cells of Cajal. Journal of Physiology, 576 (3). pp. 715-720.

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Interstitial cells of Cajal (ICC) in the urethra have been proposed as specialized pacemakers that are involved in the generation of urethral tone and therefore the maintenance of urinary continence. Recent studies on freshly dispersed ICC from the urethra of rabbits have demonstrated that pacemaker activity in urethra ICC is characterized by spontaneous transient depolarizations (STDs) under current clamp and spontaneous transient inward currents (STICs) under voltage clamp. When these events were simultaneously recorded with changes in intracellular Ca 2+ (using a Nipkow spinning disk confocal microscope) they were found to be associated with global Ca 2+ oscillations. In this short review we will consider some of these recent findings regarding the contribution of intracellular Ca 2+ stores and Ca 2+ influx to the generation of pacemaker activity in urethral ICC with particular emphasis on the contribution of reverse Na + /Ca 2+ exchange (NCX).

Item Type: Article
Uncontrolled Keywords: Interstitial cells of Cajal (ICC); Urethra: Rabbit; Urinary continence;
Subjects: Science
Research Centres: Smooth Muscle Research Centre
Depositing User: Concepta Woods
Date Deposited: 24 Nov 2011 14:07
Last Modified: 11 Nov 2014 16:10

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